UTHSC investigators safe $2.16 million to check a brand new strategy to fight neurodegenerative issues
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The National Institute on Aging just lately awarded $2.16 million to a staff of investigators from the University of Tennessee Health Science Center (UTHSC) testing a brand new strategy to fight the foundation explanation for neurodegenerative issues akin to Alzheimer’s Disease. Francesca-Fang Liao, PhD, professor of Pharmacology, Addiction Science and Toxicology within the College of Medicine, is the NIH contact principal investigator on the undertaking. Wei Li, PhD, distinguished professor within the Department of Pharmaceutical Sciences within the College of Pharmacy, is a a number of principal investigator.

Numerous progressive neurodegenerative ailments, akin to Alzheimer’s, contain the irregular accumulation of a key protein, tau, within the mind. In wholesome neurons, tau binds to and stabilizes inner help buildings referred to as microtubules, which assist information vitamins and molecules from the one a part of the nerve cell to a different. In diseased sufferers, tense alerts within the mind alter tau, inflicting it to misfold and detach from microtubules, forming neurofibrillary tangles that are poisonous to neurons.

A breakdown within the signaling pathways that may rid cells of misfolded tau and stop its accumulation is the main focus of Dr. Liao’s undertaking. Her staff is analyzing new mechamisms which may trigger these breakdowns, zeroing in on the hyperlink between oxidative stress and the exercise of a selected enzymatic molecule, otulin. In earlier research, Dr. Liao has discovered that inhibiting otulin prevented the buildup of tau. She hypothesizes that oxidative stress prompts otulin, which will increase tau aggregation and neurotoxicity. Her undertaking goals to analyze each the mechanisms that regulate tau accumulation, and the mechanisms affected by oxidative stress throughout otulin-induced tauopathies. It may also take a look at a brand new otulin-inhibiting drug developed by Dr. Li for its effectiveness in selling tau clearance and lowering tau’s mobile toxicity.

“We are extremely excited to work together as a team to further validate a potential use of this compound in translation,” Dr. Liao stated.

Posted in: Medical Research News | Medical Condition News

Tags: Addiction, Aging, Alzheimer’s Disease, Brain, Cell, Compound, Medicine, Molecule, Nerve, Neurodegenerative Diseases, Neurons, Nutrients, Oxidative Stress, Pharmacology, Pharmacy, Protein, Stress, Toxicology, Translation

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