Two UTHSC analysis groups obtain CORNET Awards for novel initiatives
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Two analysis groups on the University of Tennessee Health Science Center (UTHSC) have been awarded the 2022 UTHSC Collaborative Research Network (CORNET)-Functional Genomics Award. Each group will obtain $50,000 to help their novel initiatives.

The CORNET Awards are a aggressive intramural grant program funded by the UTHSC Office of Research to advertise new traces of interdisciplinary group examine. The program incorporates a number of completely different classes of UTHSC collaborations (UTHSC schools, UT campuses, business, regional, nationwide and worldwide). This newest spherical of funding was for UTHSC cross-college collaborations, requiring eligible groups to incorporate investigators from completely different schools. The RFP known as for initiatives that might “increase understanding of the functional consequences of genomic variation in human disease,” and “enhance on-campus capabilities for the use of model organisms.”

The awardees and their undertaking titles are:

  • “Genetic Influence of ADIPOR1 variants on Diabetes” – Djamel Lebeche, PhD, FAHA, FACC, professor within the Department of Physiology within the College of Medicine; Ivan Gerling, PhD, professor within the Division of Endocrinology, Diabetes and Metabolism within the College of Medicine; and Junaith Mohamed, PhD, assistant professor within the Department of Diagnostic and Health Sciences within the College of Health Professions. The group goals to investigate and map how mutations of a hormone receptor (ADIPOR1) result in diabetes, producing information that will reveal new drug targets for prevention. “Overall, the proposed studies will provide a rich resource that will link beta-cell functional defects to a particular signaling/regulatory pathway(s), and identify important new molecular drivers, and potentially, candidate therapeutic targets mediating Adiponectin receptor 1 genetic variations,” Dr. Lebeche mentioned.
  • “An ovarian cancer mouse model recapitulating human disease phenotype” – Junming Yue, PhD, affiliate professor within the Department of Pathology within the College of Medicine; Wei, Li, PhD, professor within the Department of Pharmaceutical Sciences within the College of Pharmacy; and Wenjing Zhang, PhD, assistant professor within the Department of Genetics and Genomics within the College of Medicine. The group goals to generate a brand new illness mannequin that mimics genetic alteration of ovarian most cancers. “This CORNET Award will help us develop our model and test preclinical drugs for ovarian cancer therapy and generate strong preliminary data for joint grant applications in the future,” Dr. Yue mentioned.

Proposals have been required to explain how findings could be utilized in future exterior funding functions. In the almost seven years because the awards have been created by Steve Goodman, PhD, vice chancellor for the Office of Research, the CORNETs have been the seed of greater than $30 million in funding for brand spanking new groundbreaking initiatives. “The CORNETs in Functional Genomics were suggested by UTHSC faculty in the first Operational Strategic Plan for Research,” mentioned Dr. Goodman. “I am so pleased that we could make this important request a reality and I want to congratulate the recipients.”

Posted in: Medical Research News

Tags: Adiponectin, Cancer, Cancer Therapy, Cell, Diabetes, Diagnostic, Drugs, Endocrinology, Genetic, Genetics, Genomic, Genomics, Hormone, Medicine, Metabolism, Model Organisms, Mouse Model, Ovarian Cancer, Pathology, Pharmacy, Phenotype, Physiology, Preclinical, Receptor, Research

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