The  impact  of  BNT162b2  mRNA  COVID-19  vaccine on  human  semen
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Scientists from Italy have just lately analyzed the impact of the mRNA-based coronavirus illness 2019 (COVID-19) vaccine on the semen high quality of grownup males. No important distinction in sperm high quality and seminal plasma parameters (oxidative stress, irritation, and electrolyte degree) has been noticed after vaccination. The research has been revealed within the journal Andrology.

Study: 4BNT162b2 mRNA Covid-19 Vaccine and semen: what do we all know? Image Credit: vchal/Shutterstock


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of the COVID-19 pandemic, is a lethal member of the human Betacoronavirus household. The virus is understood to induce all kinds of signs in contaminated individuals, starting from delicate respiratory signs to extreme pneumonia, respiratory failure, and loss of life. Apart from infecting the respiratory tract, the virus can probably impair the capabilities of different organs, together with the center, liver, gastrointestinal tract, kidney, and mind.

A handful of research have indicated that individuals contaminated with SARS-CoV-2 could develop testicular abnormalities, together with structural alteration in testicular cells, lack of integrity of the basement membrane and seminiferous tubules, and infiltration of proinflammatory mediators. However, no complete knowledge is at present out there to grasp the affect of COVID-19 vaccines on reproductive capabilities.

In the present research, the scientists have assessed the consequences of mRNA-based COVID-19 vaccine BNT162b2 (Pfizer/BioNTech) on human semen. 

Study design

The research was performed on a complete of 47 grownup males who had obtained the two-dose routine of Pfizer vaccine between February and July 2021. The semen samples had been collected from the individuals earlier than the administration of the primary vaccine dose and 70 days after the second dose.

All semen samples had been analyzed to measure sperm focus, motility, and morphology. In addition, the concentrations of reactive oxygen metabolites, electrolytes, and interleukin 6 (IL-6) had been decided utilizing seminal plasma samples.

Important observations

Among all enrolled individuals, 10% reported smoking reasonably, and 38% reported consuming alcohol socially. None of the individuals reported systemic unwanted side effects, resembling fever, allergy, or lymph node swelling.

No important adjustments in semen quantity, sperm focus, motility, and morphology had been noticed amongst individuals after COVID-19 vaccination in comparison with earlier than vaccination. 

A separate set of experiments was performed on male individuals who offered with low sperm rely or diminished sperm motility. In these individuals, no important variations in sperm parameters had been noticed after vaccination. However, the sperm parameters confirmed an bettering pattern in these individuals.

Alike sperm parameters, no important adjustments in electrolytes (calcium, chlorine, potassium, magnesium, and sodium), reactive oxygen metabolites, and IL-6 ranges had been noticed amongst individuals after vaccination.

Furthermore, no important correlations had been noticed between examined sperm parameters and electrolytes and reactive oxygen metabolites, and IL-6.

Study significance

The research findings reveal that the mRNA-based COVID-19 vaccine (Pfizer) doesn’t have any destructive affect on sperm high quality. Moreover, the vaccine doesn’t alter the degrees of electrolytes (an indicator of fine cell membrane exercise), reactive oxygen metabolites (a sign of oxidative stress), and IL-6 (an indicator of irritation).

Overall, the research highlights that the COVID-19 vaccine is protected to be used amongst males. However, the research contains solely a small variety of males with poor sperm high quality who’re extremely inclined to deteriorating sperm parameters. Moreover, because the research individuals belong to a particular inhabitants, the findings can’t be generalized to the worldwide inhabitants.

Journal reference:

  • Olana S. 2022. 4BNT162b2 mRNA Covid-19 Vaccine and semen: what do we all know? Andrology. doi: 

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