When our cells course of the oxygen we breathe and the meals we eat each day to be able to survive, they generate probably poisonous by-products popularly often called “free radicals”. Some of those molecules carry out capabilities important to the organism, but when there are too a lot of them the cells’ inner constructions could be broken, stopping the cells from functioning correctly and probably resulting in power illness. This course of is named oxidative stress.
Our our bodies include a veritable arsenal of antioxidant enzymes that assist preserve an acceptable reactive oxygen species steadiness, however these management mechanisms develop into much less environment friendly as we become older. According to an article revealed within the journal Nutrition, supplementing one’s weight-reduction plan with the amino acid taurine may very well be a viable dietary technique to fight the issue.
The examine described within the article was performed on the University of São Paulo (USP) in Brazil and concerned 24 ladies volunteers aged between 55 and 70. They had been randomly divided into two teams. One group took three 500 mg capsules of taurine per day for 16 weeks (1.5 g per day). The different took capsules containing solely corn starch (placebo). Neither the members nor the researchers knew which group every volunteer belonged to.
Markers of oxidative stress had been analyzed in blood samples collected earlier than and on the finish of the intervention. One of probably the most attention-grabbing outcomes was a rise of just about 20% in ranges of the antioxidant enzyme superoxide dismutase (SOD) within the group that acquired taurine, in contrast with a lower of three.5% within the management group. As the authors clarify, SOD protects cells in opposition to dangerous reactions of the superoxide radical.
“Preventing the buildup of free radicals that naturally occurs with aging probably prevents cardiovascular disease, diabetes and high blood pressure, among other chronic conditions,” stated Ellen de Freitas, a professor on the Ribeirão Preto School of Physical Education and Sports (EEFERP-USP) and co-principal investigator for a challenge supported by FAPESP.
According to Freitas, only a few research of the consequences of taurine within the context of ageing could be discovered within the scientific literature. “This study was a first step, aimed at investigating the ideal dose and possible side effects, none of which was observed in any of the participants,” she stated.
Taurine is a nutrient present in sure meals, reminiscent of fish, shellfish, rooster, turkey and beef. It can be naturally produced in some tissues of the human physique, particularly the liver, and is necessary to the functioning of the central nervous system, immunity, eyesight and fertility.
The group led by Freitas has studied taurine’s antioxidant and anti inflammatory results for ten years or extra, initially in high-performance athletes and later in overweight people, with day by day doses starting from 3 g to six g. “The results showed that oxidative stress in these individuals could be controlled when their diet was supplemented with this amino acid. We then decided to test the strategy in the context of aging. This was very novel, so we began with a very low safety dose,” Freitas stated.
The authentic thought was to analyze the impact of taurine supplementation mixed with train coaching, and each interventions individually. Physical exercise is taken into account one of many primary methods of modulating ranges of oxidizing substances and antioxidants within the organism, and the correct quantity is believed to spice up the advantages of taurine. However, with the arrival of the pandemic and the truth that the volunteers belonged to a high-risk group for COVID-19 problems, the researchers determined to proceed solely with the dietary a part of the examine, which may very well be monitored remotely.
Two different markers of oxidative stress had been analyzed in addition to SOD: the antioxidant enzyme glutathione reductase (GR), which decreased considerably in each teams, and malondialdehyde (MDA), which elevated 23% within the management group and decreased 4% within the taurine supplementation group.
“These results were modest, but we believe a higher dose of taurine could produce stronger evidence for its benefits,” Freitas stated.
For Gabriela Abud, first creator of the article and at present a PhD candidate on the Ribeirão Preto Medical School (FMRP-USP), modifications within the volunteers’ weight-reduction plan within the early months of the pandemic owing to lockdown might have affected the outcomes of the biochemical evaluation.
“In addition to markers of oxidative stress, we analyzed levels of minerals such as selenium, zinc, magnesium and calcium, which are important to the functioning of these enzymes,” Abud defined. “Selenium, for example, is a co-factor for glutathione peroxidase [which indirectly helps eliminate hydrogen peroxide from the organism] and was reduced in both groups.”
For Freitas, taurine supplementation is barely the “cherry on the cake” and can’t work miracles by itself. “A healthy lifestyle with a balanced diet and regular exercise is fundamental for the anti-aging effect to occur,” she stated.
In the subsequent examine, the group plan to incorporate overweight ladies aged 60-75 with sarcopenia, a gradual lack of muscle mass that may be exacerbated by power irritation. “These people face an acute risk of developing complications. We’ll offer physical training associated with taurine supplementation at 3 g per day and observe the possible alterations due to these interventions,” Freitas stated.
It is necessary to remember that the advantages and dangers of dietary taurine supplementation are nonetheless being investigated. Food dietary supplements shouldn’t be taken with out medical supervision.
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