Research supplies the essential antigenic map of SARS-CoV-2 variants of concern
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Twenty completely different COVID-19 variants have been successfully recognized and neutralized after a 3rd booster, in keeping with the brand new examine for which the University of Surrey supplied the essential antigenic map of variants of concern.

While the examine’s outcomes urged that immunity decreases 20 weeks after vaccination, a 3rd booster (of the Pfizer-BioNTech vaccine, within the case of this examine) helped the immune system to establish and neutralize the 20 completely different variants.

The antigenic map allowed the group to establish and measure how every variant impacted the immune system.

The emergence of this illness and its disruptive and lethal affect on our day-to-day lives demonstrates how essential it’s for the scientific neighborhood to work collectively to establish and characterize infectious illnesses rapidly.

The University of Surrey’s contribution to this examine via the mapping of the varied variants is itself a part of a landmark €90 million collaborative effort to sort out zoonotic illnesses in Europe, reflecting our deal with understanding the inextricable hyperlinks between the well being of animals, people and, certainly, the planet all of us share.”

Dr Daniel Horton, co-author of the examine and Reader in Veterinary Virology on the University of Surrey

The Pirbright Institute led this collaborative examine with scientists from the University of Surrey, Imperial College in London and the UK Health Security Agency (UKHSA) to know the immune response of people aged 70-89 who had obtained the Pfizer-BioNTech vaccine.

This vaccine works by triggering the immune system to create Y-shaped proteins, often called antibodies, that may keep on with the spike proteins that are discovered on the floor of the coronavirus. If an individual is contaminated with SARS-CoV-2, the antibodies bind the spike proteins stopping the virus from attaching to and getting into the human cell, due to this fact serving to to guard from extreme illness. Antibodies additionally act as a beacon to alert the immune system to assist struggle the an infection.

Dr Dalan Bailey, Head of the Viral Glycoproteins group at Pirbright, mentioned:

“Understanding how the degrees of neutralizing antibodies relate to a well-defined immune response might be an vital step in understanding how the immune system responds to SARS-CoV-2 and will additionally assist in the administration of Covid-19.

“This information could help us to understand whether the risk of breakthrough infections, hospitalization and death is increased by waning immunity or new variants. Research comparing immune responses to different SARS-CoV-2 variants and understanding the role of different mutations is vital in the management of the Covid-19 pandemic and in predicting the outcome of new variants.”

The analysis was printed in Nature Microbiology.


Journal reference:

Newman, J., et al. (2022) Neutralizing antibody exercise towards 21 SARS-CoV-2 variants in older adults vaccinated with BNT162b2. Nature Microbiology.

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