Is there an affiliation between COVID-19 vaccination and sudden sensorineural listening to loss?
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In a latest examine posted to the medRxiv* preprint server, researchers investigated a possible affiliation between coronavirus illness 2019 (COVID-19) vaccination and sudden sensorineural listening to loss (SSNHL).

Study: Sudden listening to loss following vaccination towards COVID-19. Image Credit: Brian A Jackson/Shutterstock

Several case experiences of SSNHL linked to COVID-19 vaccination have emerged in the course of the pandemic. The European database of suspected hostile drug response experiences lists over 1000 experiences of SSNHL associated to COVID-19 vaccination as of March 15, 2022. A examine in Israel reported that the chance for SSNHL elevated considerably after vaccination with Pfizer’s BNT162b2 vaccine.

The affiliation of SSNHL with extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) an infection stays controversial. One examine noticed no obvious affiliation between COVID-19 and SSNHL, whereby no affected person with SSNHL was SARS-CoV-2-positive. Nevertheless, just a few research described the incidence of SSNHL post-infection with SARS-CoV-2.

About the examine

In the current examine, researchers assessed the associations of COVID-19 vaccination and SARS-CoV-2 an infection with SSNHL. They examined SSNHL incidence in Finland between January 1, 2019, and April 12, 2022. A nationwide register harboring knowledge on start, gender, and the distinctive private identification codes of all Finnish residents, was utilized to establish all folks born or alive in the course of the examine.

People recognized with sudden listening to loss throughout 2015–18 had been excluded. Vaccination knowledge had been obtained from the nationwide vaccination register and an infection knowledge from the National Infectious Disease Register. The first SARS-CoV-2-positive check end result was utilized because the date of an infection, and recurrent infections weren’t thought-about. The first prevalence of sudden idiopathic listening to loss after January 1, 2019, was deemed an incident SSNHL case.

Vaccination standing was categorized as ‘pre-epidemic non-vaccinated,’ ‘epidemic non-vaccinated,’ and ‘vaccinated.’ The vaccination standing modified to ‘pre-vaccination’ for each particular person 30 days earlier than and to ‘vaccinated’ from the primary vaccination date. Further, the vaccinated state was stratified into major (≤ 54 days) and secondary (≥ 55 days) danger states. The an infection standing was outlined as contaminated or non-infected.

The an infection standing was non-infected for your complete cohort earlier than the COVID-19 pandemic. The contaminated state was stratified into major and secondary danger intervals following an infection. Using a Poisson regression mannequin, the researchers computed adjusted incidence charge ratios (aIRRs) between vaccine publicity states and the pre-epidemic non-vaccinated state and between an infection publicity states and the non-infected state.

Time-invariant covariates had been gender, diabetes, continual illness rely, nursing dwelling care, heart problems, variety of major care visits, assisted residing, and different institutional residing. Time-independent covariates had been vaccination/an infection standing, age teams, and calendar months. A pure spline perform was utilized, accounting for the non-linear adjustments within the SSHNL incidence by calendar month.


In the Finnish inhabitants, the crude month-to-month incidence of SSNHL was variable between 2016 and 2019, from 13 to 23 per 100,000 person-years (pyrs). After 2016, the incidence was the bottom in April (11/100,000 pyrs) and May 2020 (12/100,000 pyrs) and the best in February 2021 (27/100,000). After that, the month-to-month incidences had been variable, just like pre-2020. From January 2019 to pre-COVID-19, 1216 topics skilled SSNHL with a crude incidence of 18.7 per 100,000.

A sudden lower in SSNHL incidence was famous within the preliminary part of the pandemic (March 2020) that elevated to pre-COVID-19 ranges by the tip of 2020. The crude incidence dropped shortly after the SARS-CoV-2 vaccination program commenced in early 2021. The crude SSNHL incidences in the course of the major danger interval following first dose administration of Oxford’s ChAdOx1, BNT162b2, and Moderna’s mRNA-1273 vaccines had been 24, 20.9, and 16 per 100,000, respectively.

The aIRRs had been < 1, indicating no elevated danger of SSNHL post-first vaccination. The major and secondary danger intervals post-administration of second and third doses weren't considerably completely different than the pre-COVID-19 non-vaccinated interval. Furthermore, the authors discovered no proof that the chance of SSNHL elevated following an infection with SARS-CoV-2. The aIRRs had been 1.3 and 1.1 for the first and secondary danger intervals post-infection, implying that the SSNHL incidence was not considerably completely different relative to the non-infected interval.


The examine assessed the affiliation between SARS-CoV-2 vaccination and an infection with SSNHL, evaluating the incidence of SSNHL post-vaccination to that earlier than the COVID-19 pandemic. In conclusion, there was no proof of the suspected affiliation of COVID-19 vaccination with SSNHL, and the aIRRs had been principally ≤ 1 in the course of the major danger interval following vaccination.

*Important discover

medRxiv publishes preliminary scientific experiences that aren’t peer-reviewed and, due to this fact, shouldn’t be considered conclusive, information scientific observe/health-related conduct, or handled as established info.

Journal reference:

  • Nieminen, T. et al. (2022) “Sudden hearing loss following vaccination against COVID-19”. medRxiv. doi: 10.1101/2022.07.10.22277380. material/10.1101/2022.07.10.22277380v1

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