Study Title: “Association of Blood Viscosity with Mortality among Patients Hospitalized with COVID-19”
Journal: Journal of the American College of Cardiology – *Embargoed till July 18, 2 pm EDT
Author: Robert Rosenson, MD, Professor of Medicine (Cardiology) on the Icahn School of Medicine at Mount Sinai and Director of Cardiometabolic Disorders for the Mount Sinai Health System
Bottom Line: Patients hospitalized with COVID-19 with excessive estimated blood viscosity are at larger danger of demise from issues. High blood viscosity impairs stream to small vessels and will increase the chance of blood clots. This measure of blood thickness can be utilized as a predictor of mortality.
Why Study Is Unique: This large-scale research is the primary to judge blood viscosity within the prediction of mortality in COVID-19 sufferers. A easy calculation of blood viscosity was extra sturdy within the identification of hospitalized sufferers in danger for dying from COVID-19 issues when in comparison with frequent measures of irritation and the blood clotting biomarker D-dimer.
Why Study Is Important: Doctors usually measure hematocrit and globulins (distinction between complete protein and albumin) in all sufferers for analysis and monitoring remedy of hospitalized sufferers; nevertheless, they don’t measure blood viscosity immediately. A validated estimate of blood viscosity could be derived from the hematocrit and globulins. In this research the estimate of blood viscosity was extra strongly related to mortality in COVID-19 sufferers than different generally used danger stratification measures. This is a straightforward calculation that could possibly be added to digital medical information or lab varieties and might enhance possibilities for survival in hospitalized COVID-19 sufferers.
How Study Was Conducted: Researchers checked out information of 5,621 COVID-19 sufferers from six hospitals within the Mount Sinai Health System between February 27, 2020, and November 27, 2021. All had medical and laboratory-verified diagnoses of COVID 19 and had been recognized inside 48 hours of hospitalization and adopted till hospital discharge or demise.
What the Study Found: Hospitalized sufferers who had excessive blood viscosity had a 60 p.c larger demise fee with blood viscosity measured underneath excessive stream circumstances such because the arteries and 32 p.c larger mortality with blood viscosity measured at low stream such because the microcirculation (blood circulation within the smallest vessels), than sufferers with a low blood viscosity.
What This Means for Physicians/Patients: Blood viscosity is elevated by acute section reactants (fibrinogen, macroglobulins) which have been related to acute COVID-19 infections. Blood viscosity is an built-in measure of those acute section reactants and the mobile elements that may improve throughout an infection. When the blood viscosity is excessive, physicians could contemplate therapeutic heparin for sufferers, hydration, or intensification of glucocorticoids to reduce the severity of the acute section response to COVID-19.
Quotes: “This study demonstrates the importance of checking for blood viscosity in COVID-19 patients early in hospital admission, which is easily obtained through routine lab work. Results can help determine the best treatment course for at-risk patients and help improve outcomes,” says Dr. Rosenson. “We are currently investigating the effects of therapeutic heparin to reduce the risk of complications during acute COVID-19 infections, which may greatly benefit those with high blood viscosity.”
Choi, D., et al. (2022) Association of Blood Viscosity with Mortality amongst Patients Hospitalized with COVID-19. Journal of the American College of Cardiology. doi.org/10.1016/j.jacc.2022.04.060.
Posted in: Medical Research News | Disease/Infection News
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