High-dose supplementation of Vitamin B6 decreases nervousness
  • Reading time:5 min(s) read

In a current examine printed in Human Psychopharmacology: Clinical and Experimental, researchers reported that vitamin B6 supplementation decreased nervousness.

Study: High-dose Vitamin B6 supplementation reduces nervousness and strengthens visible encompass suppression. Image Credit: Tatjana Baibakova/Shutterstock

B nutritional vitamins play very important roles within the mobile metabolic processes, important for mind perform and the nervous system, together with those who assist keep a steadiness between neural excitation and inhibition. An equilibrium in the direction of excitation has been implicated in a number of neuropsychiatric problems, together with melancholy and nervousness. As such, it has been instructed that supplementing with high-dose vitamin B would possibly successfully increase behaviorally noticeable results of inhibition.

In one examine, topics had been supplemented with Marmite, wealthy in vitamin B, and the steady-state visible evoked potentials (SSVEPs) had been measured. They noticed decreased SSVEP amplitudes after supplementation, which implied a rise in neural inhibition or lower in excitation. The examine talked about the established position of vitamin B6 in synthesizing gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter. However, different mechanisms of motion couldn’t be dominated out, provided that Marmite is wealthy in B12 and different B nutritional vitamins.

About the examine

In the current examine, researchers investigated the results of high-dose supplementation of vitamin B6 or B12 on nervousness and melancholy. The findings offered listed below are collective outcomes of double-blind placebo-controlled trials performed over 5 years. Participants had been a normal grownup inhabitants (mainly college students) recruited in alternate for course credit score by advertorials, social media, and phrase of mouth.

Participants had been randomized to obtain vitamin B6/B12 or lactose placebo tablets. Individuals had been excluded if diabetic, lactose-intolerant, epileptic, or utilizing drugs interfering with the absorption of vitamin B. The vitamin B6 tables contained 100 mg of B6 as pyroxidine hydrochloride, and B12 tablets had 1000 μg of B12 as methylcobalamin; the doses far exceeded the really helpful every day allowance (RDA). Participants had been requested to take one pill with meals every day for 30 to 35 days.

The end result measures had been 1) display for grownup anxiety-related problems (SCAARED) [for anxiety], 2) temper and emotions questionnaire (MFQ) – lengthy model [depression], 3) visible distinction sensitivity and encompass suppression [the ability to detect low-contrast visual targets in the presence/absence of a suppressive background pattern], 4) binocular rivalry reversal price, and 5) tactile battery check [tactile sensory processing battery].


The examine comprised 478 contributors, primarily females (381), aged 18 to 58. Analysis of variance (ANOVA) of the SCAARED information of B6 and placebo cohorts revealed a big lower in nervousness post-test, primarily pushed by the decreased nervousness amongst B6 group topics. The minor discount in nervousness within the placebo group was insignificant. The ANOVA of B12 and placebo teams revealed a big decline in nervousness post-test, mainly pushed by a lower in nervousness amongst B12 group contributors.

The B6 group additionally had considerably decrease post-test scores on the generalized nervousness dysfunction (GAD) and social nervousness (SA) subscales of SCAARED. The B12 cohort had a big post-test discount on the separation nervousness (SEP) subscale. In distinction, no important modifications had been famous within the placebo group.

ANOVA evaluating B6 and placebo group information of MFQ confirmed no uniform route of change in melancholy post-test. In lieu, melancholy scores had been extra prone to lower post-test within the B6 group however improve within the placebo group; furthermore, this approached statistical significance. Nevertheless, t-tests evaluating baseline and post-test scores revealed no such important modifications. ANOVA of B12 and placebo cohort information confirmed no important modifications, and the t-test of baseline and post-test scores of the B12 group was insignificant.

A stronger encompass suppression impact was noticed within the B6 cohort, reflecting a big interplay between therapy and the absence/presence of the suppressive encompass. Follow-up t-tests revealed a big distinction within the minimal detectable degree of distinction between the 2 cohorts when encompass suppression was current and never when it was absent. 

In distinction, the distinction thresholds had been greater within the B12 group than within the placebo cohort no matter encompass suppression. However, the impact was marginally bigger when encompass was current. In the binocular rivalry reversal price, there have been no important variations between both vitamin group and the placebo cohort. Similarly, the 2 vitamin teams weren’t considerably totally different from the placebo group on any measure from the tactile battery check.


The findings instructed that vitamin B6 supplementation influenced the steadiness between neural inhibition and excitation. B6 supplementation amplified visible distinction thresholds solely within the presence of suppressive encompass. Specifically, this indicated an elevated neural inhibition by greater GABA ranges, provided that the impact of encompass suppression on distinction thresholds is triggered partly by inhibitory GABAergic interneurons.

B6 supplementation additionally decreased self-reported signs of tension. The elevated ranges of GABA would possibly clarify the noticed lower in nervousness. In distinction, B6 supplementation had no obvious impact on different end result measures (melancholy, binocular rivalry, and tactile battery assessments). Conversely, the staff discovered no obvious results of B12 supplementation on the end result measures, albeit the tendencies instructed decrease nervousness and better visible distinction thresholds.

In conclusion, the examine demonstrated that the high-dose vitamin B6 supplementation may affect nervousness and noticed that the vitamin additionally elevated surrounding suppression of visible distinction detection. Furthermore, measuring the results of different micronutrients on these end result measures would possibly assist establish the micronutrients that might be mixed and examined as a therapy for nervousness and melancholy.

Journal reference:

  • Field DT, Cracknell RO, Eastwood JR, et al. (2022). High-dose Vitamin B6 supplementation reduces nervousness and strengthens visible encompass suppression. Human Psychopharmacology: Clinical and Experimentaldoi: 10.1002/hup.2852 https://onlinelibrary.wiley.com/doi/10.1002/hup.2852

If you are interested in working in a distraction free environment, visit our site Blissful Noises where we provide various sounds and features to help you focus or relax.