Genetic testing leads to decrease size of keep within the NICU for infants with epilepsy
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Genetic testing leads to decrease size of keep within the neonatal intensive care unit (NICU) for infants with epilepsy, in response to a examine revealed within the journal Pediatric Neurology.

The discount in hospital keep time in infants with epilepsy who frolicked within the NICU was not defined by modifications within the severity of sickness, start weight or inhabitants modifications within the NICU over time. These findings affirm the significance of early genetic testing for epilepsy, which permits extra exact therapy and higher seizure management throughout a crucial time in mind growth.

Genetic testing permits us to determine the precise gene that causes an toddler’s epilepsy in order that we will begin the best therapy as early as doable. The decreased size of keep within the NICU for these infants is an indicator of improved outcomes with precision drugs.”

Andrea Pardo, MD, Study Senior Author and Medical Director of Ruth D. & Ken M. Davee Pediatric Neurocritical Care Program, Ann & Robert H. Lurie Children’s Hospital of Chicago

Pardo can also be an affiliate professor of Pediatrics at Northwestern University Feinberg School of Medicine

Approximately 15% of infants with seizures within the NICU have epilepsy, a lot of which is brought on by single gene ailments. Most NICUs now use epilepsy gene panels, which take a look at for practically 190 genes identified to trigger epilepsy. The most typical types of neonatal epilepsy are referred to as ion channelopathies, brought on by abnormalities in SCN2A and KCNQ2 genes. Matching therapy to the causal gene is named precision drugs.

In the examine, Dr. Pardo and colleagues evaluated modifications in genetic testing for neonatal onset epilepsy and related short-term outcomes over an 8-year interval amongst a cohort of NICU sufferers at Lurie Children’s earlier than and after the introduction of sponsored genetic epilepsy testing in January 2018. They included 53 infants who acquired genetic testing, 20 of which had been examined after 2018. As reference, 4,160 infants within the NICU with out genetic testing had been included.

Researchers discovered that within the genetic testing group, the size of keep decreased from 25 days pre-2018 to 19 days post-2018. Turnaround time to molecular prognosis dropped from 51 days to 17 days after 2018. However, this was not the rationale for the decreased size of keep for infants with epilepsy.

“Precision medicine resulted in improved seizure control, which is the main reason infants with epilepsy could go home sooner,” stated Dr. Pardo. “Our results show higher value with genetic testing for infants and their families, as well as the healthcare system. However, our findings still need to be validated in large, multicenter studies.”


Journal reference:

Akbari, H., et al. (2022) Genetic testing and hospital size of keep in neonates with epilepsy. Pediatric Neurology.

Posted in: Child Health News | Medical Research News

Tags: Birth Weight, Brain, Child Health, Children, Epilepsy, Gene, Genes, Genetic, Healthcare, Hospital, Intensive Care, Ion, Medicine, Neonatal Intensive Care, Neurology, Pediatrics, Precision Medicine, Research, Seizure

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