A non-coding RNA molecule regulates mitochondrial gene expression in human cells, examine reveals
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A brand new examine printed within the journal Cell reveals {that a} non-coding RNA molecule regulates mitochondrial gene expression in human cells. The work outcomes from a collaboration between the University of Gothenburg and Karolinska Institutet, each Sweden, and the University of Cologne, Germany.

Mitochondria are the powerhouses of cells and are essential for changing power from our meals into the type of power required for numerous mobile capabilities. A peculiar facet of mitochondria is the existence of a separate mitochondrial genome, which, when broken, may cause critical illnesses, affecting high-energy tissues just like the mind and coronary heart. Hence, it’s essential to check how mitochondrial gene expression is regulated to – in the long run – discover methods to manage this course of with therapies.

Human mitochondrial 7S RNA belongs to a big household of non-coding RNA molecules important for correct improvement in mammals. It was beforehand identified that ranges of mitochondrial 7S RNA range relying on the metabolic wants of the eukaryotic cell, however the molecular foundation and purposeful implications for these adjustments have been unknown. In their work, the scientists developed strategies to check the consequences of 7S RNA each on purified proteins and mitochondrial gene exercise in cells.

The most fun factor concerning the examine is that we establish a very new mechanism for regulation of mitochondrial exercise. Our findings reveal the operate of 7S RNA, a molecule recognized already 40 years in the past. Despite 7S RNA being plentiful and continuously measured in research of mitochondrial operate, its physiological function has remained an enigma till now. We are thrilled that we, in collaboration, may decide a cryo-EM construction that reveals the possible mechanism for the way 7S RNA inhibits mitochondrial gene exercise.”

Xuefeng Zhu, First Author

Xuefeng, and Xie Xie, each at University of Gothenburg, share the primary authorship of the article with Hrishikesh Das at Karolinska Insititutet.

Non-coding RNA molecules play an essential function in regulation of assorted processes within the nucleus, however an outlined function in regulation of mitochondrial operate has not beforehand been reported. “Our finding reveals a new and physiologically relevant level of regulation in human mitochondria. The challenge now is to understand how 7S RNA levels are fine-tuned in response to the metabolic needs of the human cell. We have ideas and will try to explore them in the years to come,” says Xie Xie, who carried out the work as a postdoctoral pupil at University of Gothenburg, however now works as a scientist at Pretzel Therapeutics, a start-up growing new methods to handle mitochondrial dysfunction.

“This is a new principle for regulating mitochondrial activity and future therapies targeting 7S RNA production, can be valuable”, says Maria Falkenberg, professor on the University of Gothenburg, who led the examine along with Martin Hällberg at Karolinska Insititutet. However, the sensible implications of the work will take years to discover. “These are early days, but this will open a new field in mitochondrial research” says Martin Hällberg.

Source:

Journal reference:

Zhu, X., et al. (2022) Non-coding 7S RNA inhibits transcription through mitochondrial RNA polymerase dimerization. Cell. doi.org/10.1016/j.cell.2022.05.006.

Posted in: Cell Biology

Tags: Brain, Cell, Eukaryotic cell, Food, Gene, Gene Expression, Genome, Heart, Mitochondria, Molecule, Polymerase, Research, RNA, Therapeutics, Transcription

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